Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score
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چکیده
منابع مشابه
Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation
Inherited mutations in lipopolysaccharide-responsive beige-like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B-cell and antibody deficiency (common variable immunodeficiency), inflammatory bowel disease, enlarged spleen and lymph nodes, accumulation of activated T cells and multiple autoimmune diseases. To understand the pathogenesis of the syndrome, C57BL/6 m...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2020
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2019.12.896